To truly understand female health during perimenopause and menopause, we must look deeper: into how hormonal changes influence gene expression.
This is where Hormogenomics™ comes in.
Hormogenomics™ is a groundbreaking framework pioneered by Willbe that explores how hormonal decline reprogrammes gene expression, particularly during the perimenopausal transition.
While traditional genomics focuses on inherited traits (what genes you have), Hormogenomics investigates how hormonal shifts like declining estrogen and progesterone activate or silence genes across multiple biological systems.
This shift in gene behavior is not just theoretical. It directly impacts how a woman:
• Feels (mood, motivation, sleep, stress)
• Functions (metabolism, immunity, brain performance)
• Ages (epigenetic aging, inflammation, mitochondrial resilience)
Perimenopause is not a “pause” — it’s a biological tipping point.
Hormone levels decline, but the impact isn’t linear. Instead, it triggers system-wide recalibration:
• Inflammation increases
• Neurotransmitters destabilise
• Insulin resistance builds
• Bone loss accelerates
• Mood and cognition shift
And for some women, this transition feels like falling off a cliff. For others, it’s subtle. Hormogenomics explains why.
Your symptoms aren’t random. They reflect how your genes are reacting to hormone decline.
• Metabolic Health (UCP2, AMPK, GLUT4, PPARG)
• Cardiovascular Risk (APOE, NOS3, ESR1)
• Neurodegenerative Risk (BDNF, COMT, MAOA, FKBP5)
• Bone Loss & Osteoporosis (RANKL, SOST, RUNX2)
• Mood & Mental Health (TPH2, GAD1, IL6, OXTR)
When estrogen and progesterone fall, the biochemical pathways are disrupted and your health trajectory shifts.
Most genetic testing only tells you what genes you have, and often looks at singular, isolated genes.
FemGene™, built on Hormogenomics™, goes a step further but looking at multiple gene SNPs and their cumulative systemic impact.
It shows you how your body behaves under hormonal stress and where intervention can prevent disease or optimise function. It’s not just predictive — it’s actionable.
We analyse 350+ SNPs across 125 genes, clustered into:
• Sleep & Brain Resilience
• Detox & Inflammation
• Nutrient Dependencies
• Hormone Receptor Sensitivity
• Metabolic Flexibility
Women spend 30-40 years post-menopause. That’s half our lifetime.
Hormogenomics gives us the tools to reclaim that time: not by chasing youth, but by supporting the systems that keep us healthy, strong, and mentally sharp.
It helps us transform perimenopause from a slow unraveling into a strategic health reset.
Hormogenomics™ is not just a theory. It’s a clinical paradigm shift. It changes how we:
• Predict chronic disease risk
• Personalise interventions
• Prescribe bioidentical hormone therapy
• Support healthy aging at the cellular level
If hormones and genes are your body’s codes, Hormogenomics is how those codes are read, written, and expressed.
© 2025 — Willbe, All rights reserved. Willbe & FemGene® are Trade Marks registered to Willbe Group Ltd. This product is not intended to diagnose, treat, cure, or prevent any disease.
